Ganoderma tsugae proved to protect against cardiac injury: NCKU research
Tainan, Taiwan, February 19, 2014
Dr. Fan-E Mo, a professor from the Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University (NCKU), southern Taiwan, has discovered a new effect of Ganoderma tsugae to protect from cardiac injury and identified triterpenoids as its active components against cardiac insults.
According to Dr. Mo, Ganoderma mushrooms have been widely used in traditional Chinese medicine. Ganoderma tsugae (G. tsugae), one of the ganoderma species, has been commercially cultivated in Taiwan as a dietary supplement.
G. tsugae has been subjected to different scientific studies over the recent years, most of which have shown positive results in regards to its medicinal properties.
Despite its well documented therapeutic activities, including anti-inflammation, antioxidant, and anti-tumor, the effects of G. tsugae on the heart were not clear, Mo noted.
Dr. Mo’s research findings have demonstrated an innovative effect of G. tsugae to protect the heart and identified triterpenoids as its active components against cardiac injury.
He pointed out that oxidative stress is often associated with cardiac injury and G. tsugae possesses high antioxidant activity. He hypothesized that G. tsugae protects against cardiac injury by regulating oxidative stress.
Therefore, in the study, a work-overload-induced myocardial injury model by challenging mice with isoproterenol (ISO) was used to test the cardioprotective activity of G. tsugae.
“We found that oral administration of G. tsugae effectively prevented myocardial injury in mice treated with ISO,” according to Dr. Mo.
Moreover, the triterpenoid fraction of G. tsugae, composed of a mixture of nine structurally related ganoderic acids (GAs), provided cardioprotection by inhibiting the ISO-induced expression of Fas/Fas ligand, oxidative stress, and apoptosis.
The study revealed that the cardioprotective activity of G. tsugae and identified GAs as the bioactive components against cardiac insults.
Enditem/
Dr. Fan-E Mo, a professor from the Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University (NCKU), southern Taiwan, has discovered a new effect of Ganoderma tsugae to protect from cardiac injury and identified triterpenoids as its active components against cardiac insults.
According to Dr. Mo, Ganoderma mushrooms have been widely used in traditional Chinese medicine. Ganoderma tsugae (G. tsugae), one of the ganoderma species, has been commercially cultivated in Taiwan as a dietary supplement.
G. tsugae has been subjected to different scientific studies over the recent years, most of which have shown positive results in regards to its medicinal properties.
Despite its well documented therapeutic activities, including anti-inflammation, antioxidant, and anti-tumor, the effects of G. tsugae on the heart were not clear, Mo noted.
Dr. Mo’s research findings have demonstrated an innovative effect of G. tsugae to protect the heart and identified triterpenoids as its active components against cardiac injury.
He pointed out that oxidative stress is often associated with cardiac injury and G. tsugae possesses high antioxidant activity. He hypothesized that G. tsugae protects against cardiac injury by regulating oxidative stress.
Therefore, in the study, a work-overload-induced myocardial injury model by challenging mice with isoproterenol (ISO) was used to test the cardioprotective activity of G. tsugae.
“We found that oral administration of G. tsugae effectively prevented myocardial injury in mice treated with ISO,” according to Dr. Mo.
Moreover, the triterpenoid fraction of G. tsugae, composed of a mixture of nine structurally related ganoderic acids (GAs), provided cardioprotection by inhibiting the ISO-induced expression of Fas/Fas ligand, oxidative stress, and apoptosis.
The study revealed that the cardioprotective activity of G. tsugae and identified GAs as the bioactive components against cardiac insults.
Enditem/
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Date:
103.02.11