utf-8 2024-05-09 15:48:31 2024-05-09 15:48:31 2024-04-26 2024-04-09 2024-03-28 2023-04-14 Tumor microenvironment (TME) primarily contributes to resistance in clinical antineoplastic treatment. In non-small-cell lung cancers (NSCLCs), the frequently mutated KRAS oncogene (mainly at the KRASG12C position) promotes tumor progression. The interdisciplinary research team at NCKU has successfully nano-formulated the small-molecular drug Sitravatinib (currently undergoing clinical trials internationally) using polymeric nanoparticles to form the novel nano-drug Au@PSMA-Sit. In the murine lung cancer model bearing KRASG12C mutant TME, Au@PSMA-Sit nanoparticles exhibit outstanding antitumor efficacy, requiring a lower therapeutic dosage (1/10) of sitravatinib. These experimental achievements were published in the authoritative international journal Nano Today in February 2024 with an impact factor of 17.4. Polymeric nano-formulation of spectrum selective RTK inhibitor strengthens anti-cancer effects via immune remodeling by endoplasmic reticulum stress-modulating mitochondrial metabolism ]]> 2024-02-26 2024-02-06 2024-01-26